Barely Significant
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Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia.

Neuropsychiatr Dis Treat · 2016 · PMC4841412 · PMID 27143887

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highly significantno p-value reported
In this case, the regulation of opioid synthesis by DA, which can be measured, is highly significant. 6 , 7 The hypotheses concern three main mechanisms: endorphin deficiency, the presence of abnormal endorphins, and the excess of endorphins in schizophrenia. 8 Some authors postulate that BE may have therapeutic effects in patients with schizophrenia, 9 but their findings are contradictory.

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