Protective Effects of Edaravone in Adult Rats with Surgery and Lipopolysaccharide Administration-Induced Cognitive Function Impairment.

In the fear conditioning test, hippocampal-dependent memory was assessed in a novel context and revealed highly significant impairment in the S-P group when compared to the C-P group on postoperative days 3 ( p < 0.01) and 7 ( p < 0.05) ( Fig 3A and 3B ).

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