Preliminary evidence for altered TBI pathobiology in experimental polytrauma came from mouse model featuring controlled cortical impact (CCI) combined with femoral fracture with hemorrhagic shock, with the investigators reporting a near significant trend towards elevated reactive astrocyte density in the ipsilateral hippocampus of polytrauma mice compared to CCI only mice at 4 days post-injury [ 84 ].
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The effect of concomitant peripheral injury on traumatic brain injury pathobiology and outcome.
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