Modulating Composition and Metabolic Activity of the Gut Microbiota in IBD Patients.

In one of the first placebo-controlled, double-blind trials, no difference between metrondiazole and placebo-treated patients was observed, but there was a positive trend in favour of metronidazole in individuals with the disease affecting only the colon [ 117 ].

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Oral vancomycin was tested in a double-blind controlled trial as a therapeutic approach in acute exacerbations of idiopathic colitis, but no significant difference has been found between the two treatment groups (with only a slight trend towards a reduction of surgery in the treatment group) [ 124 ].

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