a statistical trendP =0.06
For the combined effects of these genotypes, the MTHFR 677C/C+ COMT 158Met/Met genotype subjects had a 44% RHI improvement compared with a 10% improvement for MTHFR 677T/ COMT Val allele carriers; however, this just showed a statistical trend (F(3,26)=3.22, P =0.06).