In terms of HCV-specific IL-17A production, we observed no significant differences in IL-17A production at the different stages of HIV/HCV coinfection, however there was an overall trend to more HCV-specific IL-17A producing responses in the PBMC of individuals with HIV/HCV coinfection compared to those with HCV monoinfection with HCV-specific IL-17A production being significantly higher in the PBMC of individuals with chronic and acute HCV with ongoing HAART-treated HIV infection compared to those with HCV monoinfection ( p = 0.0287; p = 0.0478, respectively) ( Fig 2B ).
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HCV Specific IL-21 Producing T Cells but Not IL-17A Producing T Cells Are Associated with HCV Viral Control in HIV/HCV Coinfection.
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