Clinical validation of hrHPV testing on vaginal and urine self-samples in primary cervical screening (cross-sectional results from the Papillomavirus Dumfries and Galloway-PaVDaG study).

We hypothesise that the quality of cervical sampling deteriorates around the menopause and that menopausal atrophic changes in urogenital mucosa contribute to an increase in unsatisfactory cytology (witness the highly significant trend shown in table 1 ) and a lower content of HPV DNA in cervical samples.

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