Reduced DNA methylation patterning and transcriptional connectivity define human skin aging.

Aging Cell · 2016 · PMC4854925 · PMID 27004597

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highly significantP = 2.0e‐171actually significant

The results again indicated only minor differences between the young and old samples for most substructures, but revealed a robust and highly significant ( P = 2.0e‐171) hypermethylation of CpG islands in the old samples (Fig. 2 B).

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