highly significantp = 9.8E−06
Although, the NGS obtained methylation index of this CpG site showed moderate replication with regard to the 450K data, an interesting and highly significant hypomethylation was observed upstream of cg02450064 (40260053) in CMA boys (p = 9.8E−06) and CMA girls (p = 2.8E−06) compared to controls (Additional file 3 : Figure S2D).