A group-wise comparison of methylation levels using Mann-Whitney test with Bonferroni correction showed for each gene a highly significant difference between the “hypermethylated JMML” group and healthy controls but no difference between “normal methylation JMML” and controls (Fig. 1b, c ).
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CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia.
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