Lead identification for the K-Ras protein: virtual screening and combinatorial fragment-based approaches.

Onco Targets Ther · 2016 · PMC4861002 · PMID 27217775

Europe PMC DOI

hedged sentence

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closest p

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The sentences

considerably significantno p-value reported

The superimposed GTP-bound conformation over GDP-bound conformation was showing considerably significant conformational changes in switch-I and -II regions of active site.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.