Quantification of colony scatter confirmed a highly significant increase in cell motility following treatment with either 1 μM or 5 μM S1P ( Fig. 3A ; ρ < 0.001).
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Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2.
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