Megestrol acetate improves cardiac function in a model of cancer cachexia-induced cardiomyopathy by autophagic modulation.

Although, heart TRAF6 expression had an increasing trend, which did not reach any statistical significance, in tumour‐bearing rats of the placebo group compared with sham rats ( Figure 6 D), administration of 100 mg/kg/day MA significantly downregulated the expression of TRAF6 in the tumour group ( P < 0.01 vs. placebo; Figure 6 D).

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