Immunohistochemical and transcriptome analyses indicate complex breakdown of axonal transport mechanisms in canine distemper leukoencephalitis.

Lesions affecting the axonal cytoskeleton were characterized by a highly significant decrease in the overall axonal density as detected by persistently diminished pNF‐positive area ( P < 0.001), beginning in group 4 and ongoing to group 8 (Figs. 2 , 3 ).

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