PIAS1 is a determinant of poor survival and acts as a positive feedback regulator of AR signaling through enhanced AR stabilization in prostate cancer.

Oncogene · 2016 · PMC4865476 · PMID 26257066

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highly significantno p-value reported

20 , 23 In concordance with this hypothesis, in the present study we demonstrate a highly significant, positive correlation of PIAS1 and AR expression in tissue samples from three independent patient cohorts with a total of 753 patient samples, as well as in AR-positive PCa cell lines.

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