FlyBase annotation [ 50 ] and DAVID bioinformatic analysis [ 51 ] of the genes that are differentially expressed in response to Dop1R2 KD revealed highly significant enrichment (Benjamini corrected p -value range of 4.9E-2 to 4.8E-6) of genes falling under selected ontology (GO) term classes (i.e., heat shock response, immune response, salivary gland development, larval and pupal morphogenesis, Additional file 4 : Dataset 2).
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A critical role for the Drosophila dopamine D1-like receptor Dop1R2 at the onset of metamorphosis.
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