Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression.

Endogenous expression of miR-31 in PREC cells and RC-77N/E cells was higher than in the PCa cell lines, with a decreasing trend in the more aggressive cell lines (Figure 3A ).

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Therefore, we utilized a two-miRNA microarray approach, with stringent cutoffs, to determine which of the most highly significant miRNAs where silenced by DNA methylation or by the presence of Kaiso in PC-3 cells.

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