However, in the Morris water maze test, a test to monitor spatial working memory function, which is one of the most frequently impaired cognitive domains in patients with SZ [ 35 ], we found no significant difference between wild type and Gas7-deficient mice in latency to find the platform, although there was a slight trend for the mice to remain in the initial quadrant during the reverse phase (Additional file 6 : Figure S6B–D).
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Growth arrest specific gene 7 is associated with schizophrenia and regulates neuronal migration and morphogenesis.
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