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Impact of Genetic Polymorphism of methylenetetrahydrofolate reductase C677T on Development of Hyperhomocysteinemia and Related Oxidative Changes in Egyptian β-Thalassemia Major Patients.

PLoS One · 2016 · PMC4871363 · PMID 27187171

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an increasing trendno p-value reported
Importantly, the frequency of the mutant T allele in patients with β-TM was strongly associated with Hhcy with an estimated OR of 7.7 (95% CI: 2.8–20.9), whereas no significant association was noticed with CT genotype indicating an increasing trend to the incidence of Hhcy with TT genotype in patients with β-TM ( Table 4 ).

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