Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium.

The LD score regression analyses revealed a strong and highly significant genetic correlation ( r g =0.83, s.e.=0.15, P =1.85 × 10 −8 ) between lifetime cannabis use and lifetime cigarette smoking (based on the Tobacco Alcohol and Genetics consortium 31 summary results), implying that SNPs for lifetime cannabis use and lifetime cigarette smoking are highly correlated.

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