not quite significantP = 0.594
Interaction between MC4R rs17782313 and energy and fat intake to determine the risk of obesity There was relevant, but not quite significant ( P = 0.594), interaction between energy intake and MC4R polymorphism in determining the risk of obesity after adjusting for confounders such as age, gender, area, total activity and smoking status ( P = 0.0594; Table 4 ).