Genome-wide association study of colorectal cancer in Hispanics.

This SNP was statistically significantly associated with risk of CRC in our unconditional analysis ( P = 1.2×10 −4 ) but was borderline significant with respect to our pre-specified threshold in an analysis conditional on the region’s lead index-correlated variant, rs12474044 ( P = 2.6×10 −4 ).

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Several studies have observed an increasing trend of early-onset disease (<50 years) and a greater likelihood of late-stage tumors or metastatic disease, especially in the last few decades ( 5–9 ).

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