Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice.

Renal cortical levels of angiotensin II were not different between db/m and db/db vehicle-treated mice, however, an increasing trend was seen in the metformin-treated group vs db/m vehicle ( P = 0.096) and db/db empagliflozin ( P = 0.055, Fig. 10c ).

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