Pharmacologic agents for acute hemodynamic instability: recent advances in the management of perioperative shock- a systematic review.

This is supported by recent meta-analysis suggesting that although GDT does not improve mortality, it may reduce complications and hospital length of stay[ 43 ] and subsequent meta-analysis found a reduction in cardiovascular complications with this practice.[ 44 ] However, a follow-up large, randomized trial of perioperative GDT in high-risk patients undergoing noncardiac surgery did not definitely support the practice but did demonstrate a nonsignificant trend supporting GDT.[ 45 ] Therefore, at this point, no consensus on the true benefit of perioperative GDT exits, but further prospective study is underway.

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