Upregulation of Cyclooxygenase-2/Prostaglandin E2 (COX-2/PGE2) Pathway Member Multiple Drug Resistance-Associated Protein 4 (MRP4) and Downregulation of Prostaglandin Transporter (PGT) and 15-Prostaglandin Dehydrogenase (15-PGDH) in Triple-Negative Breast Cancer.

Breast Cancer (Auckl) · 2016 · PMC4881873 · PMID 27257388

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highly significantno p-value reported

These associations were highly significant and consistent with the classification of HPGD/15-PGDH as a tumor suppressor. 16 , 28 In order to investigate if these five PGE 2 pathway genes are associated with one another in their expression, we performed pairwise correlation analyses.

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