Hepatitis C Virus Infection Induces Autophagy as a Prosurvival Mechanism to Alleviate Hepatic ER-Stress Response.

Viruses · 2016 · PMC4885105 · PMID 27223299

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We propose that additional research is needed to determine why the interplay of chronic ER-stress, autophagy and cell survival pathways lead to liver cirrhosis and HCC induced by chronic HCV infection Understanding the mechanisms of UPR and autophagy regulation during the progression of chronic liver disease is highly significant since defective autophagy response has been linked to cancer development [ 102 ].

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