Neurogenesis, Neurodegeneration, Interneuron Vulnerability, and Amyloid-β in the Olfactory Bulb of APP/PS1 Mouse Model of Alzheimer's Disease.

The analysis of BrdU-labeled cells over time revealed an increasing trend in the GrL with aging that was statistically significant between 16 (Figure 1C ) and 43 (Figure 1D ) weeks in control animals (Figure 1G ) [Two-way ANOVA genotype vs. age: Interaction F (3, 62) = 1.846; p = 0.1482; Age F (3, 62) = 3.220; p = 0.0287; Genotype F (1, 62) = 0.0002612; p = 0.9872].

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