Can a Positive Allosteric Modulation of GABAergic Receptors Improve Motor Symptoms in Patients with Parkinson's Disease? The Potential Role of Zolpidem in the Treatment of Parkinson's Disease.

Furthermore, in PD patients there was highly significant correlation between the changes in hemispheric beta power ratio in M1 areas induced by zolpidem (significant reduction of beta power in contralateral M1 area and significant increase of beta power in ipsilateral M1 area, resulting in a hemispheric beta power ratio between the right and left M1 areas that approached parity) and the improvement induced by zolpidem on Parkinsonian motor symptoms as assessed by scores on UPDRS-III scale.

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