Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation.

The most highly significant change in Serpin abundance between wild type and dystrophic muscle was for the leukocyte elastase inhibitor Serpinb1a ( Fig. 2a ) that was increased over six-fold in dystrophic muscle compared to wild type muscle at 3 months and over seven-fold at 7.5 months ( Figs 2 a and 3 b).

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