ABC transporters P-gp and Bcrp do not limit the brain uptake of the novel antipsychotic and anticonvulsant drug cannabidiol in mice.

P-gp/Bcrp knockout mice achieved a significantly higher brain/plasma concentration ratio for 9-hydroxy risperidone than WT mice at 1 h, however P-gp knockout mice failed to reach significance when compared to WT mice at this timepoint.

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