Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution.

The finding of a highly significant overlap between CpGs that are modulated by AID expression in primary fimbrial cells and those discriminating HGSEMCs from non-serous subtypes ( Fig. 6c and Supplementary Fig. 13 ) further attests to AID's key role in triggering epigenetic reprogramming in tissues at increased risk of HGSEMC in BRCA mutation carriers.

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