Comparing the effects of tofacitinib, methotrexate and the combination, on bone marrow oedema, synovitis and bone erosion in methotrexate-naive, early active rheumatoid arthritis: results of an exploratory randomised MRI study incorporating semiquantitative and quantitative techniques.

Ann Rheum Dis · 2016 · PMC4893111 · PMID 27002108

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highly significantno p-value reported

The study met the first of its co-primary endpoints, with highly significant improvements in RAMRIS BME at month 6 observed for both tofacitinib groups versus MTX monotherapy.

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