The hypomethylating agent Decitabine causes a paradoxical increase in 5-hydroxymethylcytosine in human leukemia cells.

Sci Rep · 2015 · PMC4894448 · PMID 25901663

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an increasing trendno p-value reported

By contrast, an increasing trend of the percentage of 5hmdC/dC was noted: from 0.0015% in control cells to 0.0025% in 0.5 μM DAC-treated cells, and to 0.0037% in 3 μM DAC-treated cells ( Figure 1f ).

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