Long-Term Safety and Efficacy of Lowering Low-Density Lipoprotein Cholesterol With Statin Therapy: 20-Year Follow-Up of West of Scotland Coronary Prevention Study.

The significance of this latter finding, which should be treated cautiously because of the borderline significance and the multiple adverse effects investigated, lies in its link to historical concern that inhibition of cholesterol synthesis would lead to risk of corneal opacity. 27 , 28 Epidemiological studies have suggested both increased and decreased risk of cataracts linked to statin use. 29 – 31 However, these studies will not have the length of follow-up available in WOSCOPS or the benefits of randomization in minimizing confounding factors.

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