Loss of Dependence on Continued Expression of the Human Papillomavirus 16 E7 Oncogene in Cervical Cancers and Precancerous Lesions Arising in Fanconi Anemia Pathway-Deficient Mice.

mBio · 2016 · PMC4895109 · PMID 27190216

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0560

boldest claim

The sentences

highly significantP = 2.644 × 10 −6actually significant

In contrast, the difference in the overall severities of disease when E7 was turned off in the FancD2 -sufficient background was highly significant (for Bi-L E7 / K14 – tTA / FancD2 +/+ versus Bi-L E7 / K14 – tTA / FancD2 +/+ [Dox], P = 2.644 × 10 −6 ; P = 7.9 × 10 −6 if we exclude cancers).

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marginally significantP = 0.056so close (0.05 < p ≤ 0.1)

We observed a decrease in proliferation in Bi-L E7 / K14 – tTA / FancD2 +/+ mice treated with doxycycline that was marginally significant ( P = 0.056) compared to that observed in Bi-L E7 / K14 – tTA / FancD2 +/+ mice not treated with doxycycline.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.