An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation.

A ‘volcano plot’ of the log-transformed fold-change of H3K27me3 peak signal versus log transformed P value demonstrated that the peaks with most highly significant change between Ezh2 +/+ and Ezh2 Y641F/+ samples were those that decreased 2–4 fold in Ezh2 Y641F/+ cells.

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