Functional and pharmacological characterization of two different ASIC1a/2a heteromers reveals their sensitivity to the spider toxin PcTx1.

Although the difference in apparent H + affinity between the two concatamers was highly significant (p < 0.001), it was rather slight (0.3 pH units), suggesting that the contribution of individual subunits to apparent H + affinity is not simply additive but that apparent H + affinity is rather determined by the complex interaction of all three subunits.

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