Neonatal diabetes caused by a homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensitivity markedly affect diabetes risk.

Diabetologia · 2016 · PMC4901145 · PMID 27118464

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highly significantno p-value reported

Although the increase in risk is relatively small (OR 1.18), it is highly significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.