A meta-analysis documented that the Q192R polymorphism is the sole genetic variant in the PON1 gene to show a highly significant, albeit small (7% per R allele), risk for coronary heart disease [ 19 ] and another independent meta-analysis estimated a 10% risk excess per R allele for the same outcome [ 20 ].
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A Genetic Biomarker of Oxidative Stress, the Paraoxonase-1 Q192R Gene Variant, Associates with Cardiomyopathy in CKD: A Longitudinal Study.
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