89 A recent study evaluated the concordance of promoter hypermethylation of candidate genes, including CDKN2A, DAPK1, DCC, MGMT, MINT31, and TIMP3 , between salivary rinses collected with or without an exfoliating brush from identical HNSCC patients and revealed a highly significant positive correlation between data obtained using the 2 methods. 90 Conclusion and Future Perspectives Epidemiologic and clinical studies have highlighted an unexpected heterogeneity in HNSCC regarding its etiology as well as environmental, cellular, and molecular features.
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Predictive value of epigenetic alterations in head and neck squamous cell carcinoma.
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