Mucosal and blood-brain barrier transport kinetics of the plant N-alkylamide spilanthol using in vitro and in vivo models.

BMC Complement Altern Med · 2016 · PMC4907212 · PMID 27296455

Europe PMC DOI

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highly significantno p-value reported

Furthermore, once present in the systemic circulation, spilanthol rapidly penetrated the blood-brain barrier: a highly significant influx of spilanthol into the brains was observed with a unidirectional influx rate constant K 1 of 796 μl/(g · min).

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