Five endometrial cancer risk loci identified through genome-wide association analysis.

All five SNPs were associated with endometrial cancer at genome-wide significance (P<5×10 −8 , Table 1 , Figure 2 , Figure 3 ), and these associations remained highly significant when analysis was restricted to cases with endometrioid subtype only.

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Since there may be significant variation in tumour tissue copy number, somatic CNVs were taken into account by regressing gene expression to average copy number spanning the gene.

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