HLA class I molecular variation and peptide-binding properties suggest a model of joint divergent asymmetric selection.

According to the linear regression model that we used to analyze H CODON_MAX in relation to both the “locus” and the “pockets” (i.e., location of residues within or outside the four PBR pockets) variables (Supplementary Table S1a, Online Resource 2 ), the global F statistic is highly significant and both variables are significant predictors of the entropy ( p < 0.05 or <0.01 for “locusA” to “locusC” and “pocketA” to “pocketF”).

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