highly significantp= 0.0051
These meta-analyses substantially confirmed a reduction of bleeding, without a significant reduction of mortality rate in patients treated with bivalirudin; however a re-evaluation of current data adding MATRIX study patients demonstrate for the first time highly significant benefits of radial access in acute coronary syndrome patients for major adverse cardiovascular events (p= 0.0051) and all-cause mortality (p= 0.0011) in patients treated with bivalirudin 19 .