Barely Significant
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Long-term study of the impact of methotrexate on serum cytokines and lymphocyte subsets in patients with active rheumatoid arthritis: correlation with pharmacokinetic measures.

RMD Open · 2016 · PMC4913203 · PMID 27335660

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highly significantno p-value reported
We report highly significant decreases in serum IL-1B, IL-6 and IL-8 on start of MTX.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.