Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.

The association signal was also highly significant when analysis was confined to B-cell ALL (combined OR = 1.73, 95% CI: 1.61 – 1.85; P = 9.31 x 10 -20 ; Table 1 , Supplementary Table 1 ). rs6944602 and rs6964823 which map to the 3’ UTR and intron 7 of IKZF1 (50,441,245 bps and 50,427,590 bps; Fig. 1 ; Supplementary Fig. 4 ), also displayed statistical support for an association at 7p12.2 at genome-wide threshold ( P = 6.02 x 10 -14 and 3.43 x 10 -15 respectively). rs4132601, rs6964823 and rs6944602 map to a 27.3kb block of linkage disequilibrium (LD).

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