highly significantp -values = 0
With 10,000 iterations of random shuffling of the enhancer predictions in the H1 genome, we found the average validation rate of distal DHS, p300 and TF to be 13.0%, 1.1% and 4.2%, respectively, and the actual validation rates were highly significant according to a one-sided t -test ( p -values = 0) ( Fig. 1B ).