Secondary patient outcomes None of the secondary outcomes were significantly different between intervention and control groups, though anxiety ( p = 0.08) and depression ( p = 0.06) measured by the HADS were of borderline significance in favour of the CARE Plus group, although the effects sizes were relatively small.
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The CARE Plus study - a whole-system intervention to improve quality of life of primary care patients with multimorbidity in areas of high socioeconomic deprivation: exploratory cluster randomised controlled trial and cost-utility analysis.
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