ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain.

PLoS One · 2016 · PMC4917252 · PMID 27333281

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The electrophysiological findings were confirmed in calcium imaging experiments ( Fig 6C ) where large and highly significant H 2 O 2 responses were found in nv TRPM2-3xHA and nv TRPM2-ΔNUD-3xHA but never in untagged nv TRPM2.

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