a statistical trendp = 0.1
In aggregate, X4 (median IC 50 : 161.7, range: 122.8–179.6) as compared to R5 (median IC 50 : 425.3, range: 174.5–684.8) viruses showed a statistical trend of around 3 fold greater neutralization resistance to the pooled R5 plasma (p = 0.1, paired Wilcoxon rank sum test) ( Fig. 2 e).